• Mixture of substrates, Internal standards and detergent for 50 duplex assay of Palmitoyl Protein Thioesterase 1 and Tripeptidyl Peptidase 1 enzymes by mass spectrometry.

• Comes with the relevant buffer.

• Comes with the enzymatic products relevant to the PPT1 and the TPP1 assays, for mass spectrometry tuning and standard curve generation (See Absolute Quantification).

"Minimum order quantity: 5 vials (250 duplex assays)"

CLN1;CLN2;neuronal ceroid lipofuscinoses; NCL

Duplex Assay Cocktail of Palmitoyl Protein Thioesterase1 &Tripeptidyl Peptidase1

SKU: CD1

The mixture contains product numbers: SM34A (MW=638.80), HA19A (MW=358.52), SMF30A (MW=564.73), HA16A (MW=358.35) and octyl glucoside detergent (MW =‎292.37).
In the unlikely event that our product does not meet the information provided on the Specification Sheet (provided with each item), please contact us at: contact@gelbchem.com for a Return Authorization Number. To receive a full refund you must return at least 90% of the material received in its original condition and within 30 days of receipt of the compound. Refunds will be made within 30 days of receipt of the compound. A Return Authorization Number is required, and return postage is to be paid by the customer.
Liu, Y., Yi, F., Kumar, A.B., Chennamaneni, N.K., Hong, X., Scott, C.R., Gelb, M.H. and Turecek, F., 2017. Multiplex tandem mass spectrometry enzymatic activity assay for newborn screening of the mucopolysaccharidoses and type 2 neuronal ceroid lipofuscinosis. Clinical chemistry, 63(6), pp.1118-1126.

Khaledi, H., Liu, Y., Masi, S. and Gelb, M.H., 2018. Detection of Infantile Batten Disease by Tandem Mass Spectrometry Assay of PPT1 Enzyme Activity in Dried Blood Spots. Analytical Chemistry. 90(20), 12168-12171.

Hong, X., Sadilek, M. and Gelb, M.H., 2020. A highly multiplexed biochemical assay for analytes in dried blood spots: application to newborn screening and diagnosis of lysosomal storage disorders and other inborn errors of metabolism. Genetics in Medicine, 22(7), pp.1262-1268.

Duplex Assay Cocktail of Palmitoyl Protein Thioesterase1 &Tripeptidyl Peptidase1

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